A new perspective on the possibility of chronic pain therapy through physical exercise

Abstract

The paper reviews the literature on pathophysiology of mitochondria and the
involvement of these cellular organisms in pain therapy through physical activity. The main
algogenic mechanism of mitochondrial dysfunctions - cellular respiration disorders, can be
countered by endurance effort. Endurance exercises can also improve the morphofunctionality
of neuronal mitochondria, thus being effective in treating pain associated with
Alzheimer's disease. During recovery after endurance training, exacerbation of incisional pain
may occur, which can be alleviated by the administration of resveratrol. Coenzyme Q10 may
be used as an adjuvant to exercise pain therapy. Exercise can also treat inflammatory pain by
promoting the anti-inflammatory phenotype of macrophages.